Integrate multiple modes of biology from a single sample in a single experiment to provide transformative insights into health and disease.
Discover our new software tool for exploring 6-base analysis.
Current technologies are unable to reliably resolve both genetic and epigenetic sequences at low sample input and miss important information. biomodal’s duet multiomics solution evoC gives you access to the 6-base genome – all four canonical bases and distinguishes 5‑methylcytosine (5mC) and 5‑hydroxymethylcytosine (5hmC) – from a single 5ng DNA sample, in a single experiment, with high accuracy.
Combined epigenetic and genetic analysis in a single sequencing run lets you access the most critical information from your DNA samples.
Better characterise liquid biopsy and genomic DNA samples of early stage cancer for diagnostic and therapy development.
Combined data reveals the role of methylation in neurodegeneration.
Pinpoint epigenetic changes that determine patterns of disease and health throughout a lifespan.
Improved DNA-based diagnostics with the ability to see disease-relevant changes from low input samples
Detect minute epigenetic changes to better understand maternal and foetal health.
A true 6-base genome that distinguishes 5mC and 5hmC together with all four canonical bases to measure multiple modes of biology
Assess all four canonical bases plus modified cytosine
Serial plasma dual 5mC/5hmC profiling moved liquid biopsy beyond mutation detection toward transcriptome-like tumor-state and resistance monitoring in mCRPC
The ssDNA duet workflow achieves ultra‑low limits of detection by combining high material recovery with outstanding sensitivity and specificity across genomic and epigenetic features.
We investigated the impact of a duet single stranded ligation workflow on methylation LoD (further details on duet single stranded ligation workflow are provided in poster #121) across duet +modC (which provides 5-base data) and duet evoC (which provides 6-base data, distinguishing between 5mC and 5mC).
We can help you reveal new data and multimodal insights from your research.
