Better biological insights start with better data.
Genetics, epigenetics and biology. All without compromise.
Introducing the duet mosaic family — optimized for cfDNA workflows.
Why biomodal?
The most important biological insights often emerge at the intersection of genetics and epigenetics. Yet conventional approaches force researchers to choose between high-quality genetic data or methylation information, and require a complex integration of results from multiple workflows.
biomodal was founded to solve this problem, built on a simple belief: researchers shouldn't have to compromise.
Genetics without compromise
Preserve accurate genetic variant detection while generating epigenetic information from the same, low-input sample. Unlike conventional methylation workflows, biomodal technologies retain confidence in C>T variant detection and other biologically important genetic features.
Epigenetics without compromise
Generate methylation data with exceptional sensitivity and specificity, reducing false-positive calls and missed events while increasing confidence in biological interpretation.
Biology without compromise
Access integrated genetic and epigenetic information from the same sample, the same DNA molecule, to investigate disease mechanisms, biological activity, gene regulation, and biomarker discovery from a single dataset.
Software without lock-in
Analyze your data your way. biomodal provides pipelines that can run on local workstations, HPC environments, or cloud infrastructure using community-standard outputs and tools designed for multiomic analysis. All standard and included with the duet technology.
Explore the duet platform
Have it all. Without compromise.
The duet platform enables integrated genetic and epigenetic analysis from the same sample, helping researchers generate richer biological insights from every experiment.
duet 6-base mosaic
From every fragment, the full picture.
Maximize insight from every precious sample by using single-stranded ligation to read genetics, 5mC, 5hmC and fragmentomics from the same molecule. Ideal for cfDNA and liquid biopsy.
Explore duet 6-base mosaicduet +modC mosaic
Every fragment. The essential picture.
Using single-stranded ligation, read genetics, modC and fragmentomics together from the same molecule gaining highly accurate insights from every cfDNA sample.
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duet evoC
Resolve genetics and complete epigenetics on the same molecule.
duet 6-base delivers genetics, 5mC and 5hmC as distinct signals from a single sample across gDNA, FFPE and cfDNA, revealing biology that combined-readout traditional methods miss.
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duet +modC
Integrated genetics and methylation from the same sample.
duet +modC measures genetic variants and modified cytosine together from a single sample, across gDNA, FFPE and cfDNA, with market-leading sensitivity, specificity and genetic accuracy.
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Explore biology in every mode.
From fundamental biology to translational and clinical research, biomodal technologies help researchers investigate how genetics and epigenetics shape health and disease.
Cancer research
Investigate the genetic and epigenetic drivers of disease, understand mechanisms of resistance, and identify biologically meaningful biomarkers.
Liquid biopsy
Generate integrated insights from low-input samples for disease detection, monitoring, and characterization.
Precision medicine
Understand how genetic and dynamic epigenetic changes drive disease progression and treatment responses over time.
Neurodegenerative disease
Study the regulatory changes and cellular states associated with neurodegeneration.
Researchers are uncovering new biology with biomodal.
Integrated genetic and epigenetic analysis is already helping researchers investigate disease biology, discover biomarkers, and understand mechanisms of regulation across cancer, immunology, neurobiology, and translational research.
View publications and resourcesIntegrative liquid biopsy reveals resistance mechanisms in prostate cancer, with NCI's Adam Sowalsky, PhD
Learn how 6-base sequencing can reveal a more dynamic, non-invasive view of treatment response and disease progression.
Watch webinarGenetic and epigenetic dysregulation of CR1 is associated with catastrophic antiphospholipid syndrome
See how combined genetic and epigenetic analysis can reveal disease-associated biological mechanisms.
Read publicationOGT prevents DNA demethylation and suppresses expression of transposable elements by restraining TET activity genome-wide
Discover how independent 5mC and 5hmC measurements reveal new insights into genome-wide regulation.
Read publicationTrusted by researchers exploring the most important questions in biology.
- Integrated genetic and epigenetic analysis
- Multiomic biomarker discovery
- Disease mechanism research
- Gene regulation studies
- Translational research
- Liquid biopsy innovation
Ready to see more biology?
Explore the duet platform and discover how integrated genetic and epigenetic analysis can help answer your next biological question.